Effect Of Adenotonsillectomy In Children With Sleep-Disordered Breathing

Main Category: Ear, Nose and Throat
Also Included In: Sleep / Sleep Disorders / Insomnia
Article Date: 21 Dec 2011 – 0:00 PST

email icon email to a friend   printer icon printer friendly   write icon opinions  

not yet rated 3 stars
Children may have a better quality of life (QOL) and diminished cardiovascular disease risk from the decreased endothelin 1 (ET-1) levels after adenotonsillectomy, according to new research published in the December 2011 issue of Otolaryngology – Head and Neck Surgery.

SDB is an increasingly common indication for tonsillectomy and adenoidectomy due to obstructive sleep apnea syndrome (OSAS). Cardiovascular (CV) disease frequently has been reported in patients with moderate to severe OSAS, related abnormalities include: systematic hypertension , pulmonary hypertension with corpulmonale, left ventricular (LV) hypertrophy or dysfunction, cardiac arrhythmias , atherosclerosis, and coronary artery disease .

The study sample included an obstructive sleep apnea survey and a detailed personal and family history. All subjects underwent a complete otolaryngologic examination, otoscopy, and anterior rhinoscopy. Thirty-seven children with a diagnosis of upper airway obstruction caused by adenotonsillar hypertrophy (ATH) were included in the study. Twenty female and 17 male patients, between 3 and 13 years old participated in the study.

Surgical procedures included: 20 tonsillectomies and adenoidectomies (54%), 15 adenoidectomies only (40.6%), and 2 tonsillectomies only (5.4%). Study results show when comparing moderate and severe cases to mild cases according to Brouilette scores, ET-1 levels were significantly higher in moderate and severe cases (P <.01). There was a significant correlation between ET-1 and the OSA-18 survey scale (r =0.442; P =.001).

The objective of the study was to evaluate the influence of adenotonsillectomy on the plasma concentration of ET-1 levels and C-reactive protein (CRP) in children with sleep-disordered breathing (SDB). The primary goal of this research study was to investigate the effect of ATH and adenotonsillectomy on the possible pathogenic mechanisms (endothelial dysfunction and inflammation) that lead to cardiovascular complications.

Based on the study findings, the authors indicate: “…that children with SDB who undergo adenotonsillectomy may have a better QOL, and the positive influence of adenotonsillectomy on CV function might be mediated by the decrease in ET-1 levels.” The study’s authors acknowledge that more research is needed, noting: “Further studies with longer follow-up and a larger population sample are warranted to demonstrate the association between SDB due to ATH and ET-1 levels and to confirm the influence of adenotonsillectomy on ET-1 and CRP levels to prevent cardiovascular disease in children.”

Article adapted by Medical News Today from original press release. Click ‘references’ tab above for source.
Visit our ear, nose and throat section for the latest news on this subject. The study “Effect of Adenotonsillectomy on Endothelin-1 and C-Reactive Protein Levels in Children with Sleep-Disordered Breathing”

American Academy of Otolaryngology – Head and Neck Surgery

Please use one of the following formats to cite this article in your essay, paper or report:

MLA

American Academy of Otolaryngology – Head and Neck. “Effect Of Adenotonsillectomy In Children With Sleep-Disordered Breathing.” Medical News Today. MediLexicon, Intl., 21 Dec. 2011. Web.
8 Jan. 2012. APA

Please note: If no author information is provided, the source is cited instead.


Rate this article:
(Hover over the stars then click to rate)

Please note that we publish your name , but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form .

Please send any medical news or health news press releases to:

Note : Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions .


View the original article here